The system Ho–Ni–In at 870 K

Annali 870

The autoptic incidence of non-parasitic hepatic benign cystic disease is estimated between 0.14 and 0.3 % (1, 2). The symptomatic cysts are even more rare (10-15% of the cysts) (3, 4). In the past such pathology has been surgically approached in different ways (fenestration, resection, enucleation, cysto-enterostomies) and at times non-invasively, the results of which were mediocre (5, 6, 7, 8,...

Effective Parameters on the Partition Coefficient of Guanidine Hydrochloride in the Poly (Ethylene Glycol) +Phosphate +Water System at 298.15 K

Dmd048157 870..877

Anastrozole belongs to the nonsteroidal triazole-derivative group of aromatase inhibitors. Recently, clinical trials demonstrated improved antitumoral efficacy and a favorable toxicity with third-generation aromatase inhibitors, compared with tamoxifen. Anastrozole is predominantly metabolized by phase I oxidation with the potential for further phase II glucuronidation. It also, however, is sub...

Dmd061523 870..883

It is important to examine the cytochrome P450 2C19 (CYP2C19) genetic contribution to drug disposition and responses of CYP2C19 substrates during drug development. Design of such clinical trials requires projection of genotype-dependent in vivo clearance and associated variabilities of the investigational drug, which is not generally available during early stages of drug development, but is ess...

Mean Activity Coefficients Measurements and Thermodynamic Modeling of the Ternary Mixed Electrolyte KCl + Lactose + Water System at T = 298.15 K

In this work, the mean activity coefficients of KCl in the KCl+lactose +water system were determined using the potentiometric method. The electromotive force measurements were carried out on the galvanic cell without liquid junction of the type: Ag|AgCl|KCl (m), lactose (wt.%), H2O (1−wt.) %|K-ISE, in various mixed solvent systems containing 0, 5,7.5, 10 and 12.5 % mass fractions of lactose. Th...